Ten-player Northern Ireland suffered a home defeat to Group H leaders Slovenia after the visitors earned a scrappy 1-0 win at Windsor Park.
Manager Michael O'Neill admitted Northern Ireland's hopes of reaching Euro 2024 were over after their fourth straight qualifying loss, a 4-2 reverse in Slovenia.
Switzerland inflicted Portugal's first UEFA Nations League defeat to put Spain top of Group A2 on Sunday evening.
Anthony Martial rescued a point for France in Ukraine as their winless run extended to five games, while the Netherlands thrashed Montenegro 4-0.
France were held by Ukraine as the defence of their World Cup title started with a 1-1 draw in Paris, while Tomas Soucek scored a hat-trick for Czech Republic.
Michy Batshuayi scored twice as Belgium came from behind to beat Switzerland 2-1 in a friendly ahead of their crucial Nations League clash against England on Sunday.